Neurodegeneration Informatics Laboratory

Research

Welcome to the Neurodegeneration Informatics lab based at the University of Cambridge. Our work has two main focuses.

Firstly, we seek to understand how neurodegenerative disease affects the whole brain, using a combination of brain imaging, pathology data, genetic information and clinical testing. We particularly focus on diseases where a protein called tau builds up within brain cells. These include Progressive Supranuclear Palsy and Corticobasal Syndrome.

Secondly, we aim to develop and implement artificial intelligence and machine learning methods for use in memory clinics. We regularly uses these kind of advanced mathematical tools in our research work, and we are keen to use them in a way that will help people with neurodegenerative diseases and the doctors and other health professionals they see in clinics. This work is organised through the Quantitative MRI in NHS Memory Clinics (QMIN-MC) study.

Below are selected citations from our lab that will give you an idea of what we do.

2024

Liz Yuanxi Lee, Delshad Vaghari, Michael C. Burkhart, Peter Tino, Marcella Montagnese, Zhuoyu Li, Katharina Zühlsdorff, Joseph Giorgio, Guy Williams, Eddie Chong, Christopher Chen, Benjamin R. Underwood, Timothy Rittman, Zoe Kourtzi
eClinicalMedicine  ·  12 Jul 2024
Marcella Montagnese, Timothy Rittman
The Lancet Healthy Longevity  ·  01 Apr 2024
Axel A. S. Laurell, Ashwin V. Venkataraman, Tatjana Schmidt, Marcella Montagnese, Christoph Mueller, Robert Stewart, Jonathan Lewis, Clare Mundell, Jeremy D. Isaacs, Mani S. Krishnan, Robert Barber, Timothy Rittman, Benjamin R. Underwood
The British Journal of Psychiatry: The Journal of Mental Science  ·  18 Jan 2024

2023

Tanrada Pansuwan, Annelies Quaegebeur, Sanne S. Kaalund, Eric Hidari, Mayen Briggs, James B. Rowe, Timothy Rittman
Acta Neuropathologica Communications  ·  09 Nov 2023
Laura M. Winchester, Eric L. Harshfield, Liu Shi, AmanPreet Badhwar, Ahmad Al Khleifat, Natasha Clarke, Amir Dehsarvi, Imre Lengyel, Ilianna Lourida, Christopher R. Madan, Sarah J. Marzi, Petroula Proitsi, Anto P. Rajkumar, Timothy Rittman, Edina Silajdžić, Stefano Tamburin, Janice M. Ranson, David J. Llewellyn
Alzheimer's & Dementia: The Journal of the Alzheimer's Association  ·  31 Aug 2023
Robin J. Borchert, Tiago Azevedo, AmanPreet Badhwar, Jose Bernal, Matthew Betts, Rose Bruffaerts, Michael C. Burkhart, Ilse Dewachter, Helena M. Gellersen, Audrey Low, Ilianna Lourida, Luiza Machado, Christopher R. Madan, Maura Malpetti, Jhony Mejia, Sofia Michopoulou, Carlos Muñoz-Neira, Jack Pepys, Marion Peres, Veronica Phillips, Siddharth Ramanan, Stefano Tamburin, Hanz M. Tantiangco, Lokendra Thakur, Alessandro Tomassini, Ashwati Vipin, Eugene Tang, Danielle Newby, The Deep Dementia Phenotyping (DEMON) Network, Janice M. Ranson, David J. Llewellyn, Michele Veldsman, Timothy Rittman
Alzheimer's & Dementia  ·  15 Aug 2023
David J. Whiteside, Duncan Street, Alexander G. Murley, P. Simon Jones, Maura Malpetti, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, Alexander Gerhard, Michele T. Hu, Johannes C. Klein, P. Nigel Leigh, Alistair Church, David J. Burn, Huw R. Morris, James B. Rowe, Timothy Rittman
Human Brain Mapping  ·  01 Aug 2023
Tiago Azevedo, Richard A. I. Bethlehem, David J. Whiteside, Nol Swaddiwudhipong, James B. Rowe, Pietro Lió, Timothy Rittman, Alzheimer’s Disease Neuroimaging Initiative
Communications Medicine  ·  20 Jul 2023
Timothy Rittman
Biological Psychiatry  ·  01 May 2023

2022

David J. Whiteside, Maura Malpetti, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Isabelle Le Ber, Alexander Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, Arabella Bouzigues, Lucy L. Russell, Jonathan D. Rohrer, James B. Rowe, Timothy Rittman, The GENFI Consortium
Alzheimer's & Dementia  ·  01 Nov 2022
Nol Swaddiwudhipong, David J. Whiteside, Frank H. Hezemans, Duncan Street, James B. Rowe, Timothy Rittman
Alzheimer's & Dementia  ·  13 Oct 2022
R. A. I. Bethlehem, J. Seidlitz, S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, S. Adler, G. S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D. E. Astle, B. Auyeung, M. Ayub, J. Bae, G. Ball, S. Baron-Cohen, R. Beare, S. A. Bedford, V. Benegal, F. Beyer, J. Blangero, M. Blesa Cábez, J. P. Boardman, M. Borzage, J. F. Bosch-Bayard, N. Bourke, V. D. Calhoun, M. M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y. S. Chong, J. H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V. L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. A. Devenyi, M. A. Di Biase, R. Dolan, K. A. Donald, G. Donohoe, K. Dunlop, A. D. Edwards, J. T. Elison, C. T. Ellis, J. A. Elman, L. Eyler, D. A. Fair, E. Feczko, P. C. Fletcher, P. Fonagy, C. E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J. H. Gilmore, D. C. Glahn, I. M. Goodyer, P. E. Grant, N. A. Groenewold, F. M. Gunning, R. E. Gur, R. C. Gur, C. F. Hammill, O. Hansson, T. Hedden, A. Heinz, R. N. Henson, K. Heuer, J. Hoare, B. Holla, A. J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C. R. Jack, A. P. Jackowski, T. Jia, K. A. Johnson, P. B. Jones, D. T. Jones, R. S. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E. A. Kelley, S. Kern, K. W. Kim, M. G. Kitzbichler, W. S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J. D. Lewis, J. Li, W. Liao, C. Liston, M. V. Lombardo, J. Lv, C. Lynch, T. T. Mallard, M. Marcelis, R. D. Markello, S. R. Mathias, B. Mazoyer, P. McGuire, M. J. Meaney, A. Mechelli, N. Medic, B. Misic, S. E. Morgan, D. Mothersill, J. Nigg, M. Q. W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P. M. Pan, C. Pantelis, M. M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C. K. Rollins, R. Romero-Garcia, L. Ronan, M. D. Rosenberg, D. H. Rowitch, G. A. Salum, T. D. Satterthwaite, H. L. Schaare, R. J. Schachar, A. P. Schultz, G. Schumann, M. Schöll, D. Sharp, R. T. Shinohara, I. Skoog, C. D. Smyser, R. A. Sperling, D. J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K. A. Tsvetanov, N. B. Turk-Browne, J. J. Tuulari, C. Tzourio, É Vachon-Presseau, M. J. Valdes-Sosa, P. A. Valdes-Sosa, S. L. Valk, T. van Amelsvoort, S. N. Vandekar, L. Vasung, L. W. Victoria, S. Villeneuve, A. Villringer, P. E. Vértes, K. Wagstyl, Y. S. Wang, S. K. Warfield, V. Warrier, E. Westman, M. L. Westwater, H. C. Whalley, A. V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H. J. Zar, A. Zettergren, J. H. Zhou, H. Ziauddeen, A. Zugman, X. N. Zuo, E. T. Bullmore, A. F. Alexander-Bloch
Nature  ·  06 Apr 2022
Duncan Street, David Whiteside, Timothy Rittman, James B. Rowe
Parkinsonism & Related Disorders  ·  01 Feb 2022
Kun Zhao, Qiang Zheng, Martin Dyrba, Timothy Rittman, Ang Li, Tongtong Che, Pindong Chen, Yuqing Sun, Xiaopeng Kang, Qiongling Li, Bing Liu, Yong Liu, Shuyu Li
Advanced science  ·  31 Jan 2022

2021

Janice M. Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J. Mummery, Blossom C. M. Stephan, Daniele Altomare, Giovanni B. Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J. Llewellyn, European Task Force for Brain Health Services
Alzheimer's Research & Therapy  ·  11 Oct 2021
David J. Whiteside, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, Alexander Gerhard, Michele T. Hu, Johannes C. Klein, P. Nigel Leigh, Alistair Church, David J. Burn, Huw R. Morris, James B. Rowe, Timothy Rittman
Neurobiology of Aging  ·  16 Jul 2021
James B. Rowe, Negin Holland, Timothy Rittman
Practical Neurology  ·  01 Jul 2021

2020

Fraser S. Brown, James B. Rowe, Luca Passamonti, Timothy Rittman
Movement Disorders Clinical Practice  ·  01 Dec 2020
Timothy Rittman
Journal of Neurology  ·  07 Jul 2020
Marta M. Correia, Timothy Rittman, Christopher L. Barnes, Ian T. Coyle-Gilchrist, Boyd Ghosh, Laura E. Hughes, James B. Rowe
Brain Communications  ·  01 Jan 2020

2019

Robin J. Borchert, Timothy Rittman, Charlotte L. Rae, Luca Passamonti, Simon P. Jones, Deniz Vatansever, Patricia Vázquez Rodríguez, Zheng Ye, Cristina Nombela, Laura E. Hughes, Trevor W. Robbins, James B. Rowe
Brain communications  ·  01 Jun 2019
Timothy Rittman, Robin Borchert, Mr Simon Jones, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre Mendonça, Sandro Sorbi, Jonathan D Rohrer, James B. Rowe, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Sandra Black, Martina Bocchetta, Sergi Borrego-Ecija, Jose Bras, Rose Bruffaerts, Paola Caroppo, David Cash, Miguel Castelo-Branco, Rhian Convery, Thomas Cope, Maura Cosseddu, María de Arriba, Giuseppe Di Fede, Zigor Díaz, Katrina M. Dick, Diana Duro, Chiara Fenoglio, Camilla Ferrari, Catarina B. Ferreira, Toby Flanagan, Nick Fox, Morris Freedman, Giorgio Fumagalli, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Stefano Gazzina, Roberta Ghidoni, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Carolin Heller, Tobias Hoegen, Begoña Indakoetxea, Vesna Jelic, Lize Jiskoot, Hans-Otto Karnath, Ron Keren, Maria João Leitão, Albert Lladó, Gemma Lombardi, Sandra Loosli, Carolina Maruta, Simon Mead, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Benedetta Nacmias, Mollie Neason, Jennifer Nicholas, Linn Öijerstedt, Jaume Olives, Alessandro Padovani, Jessica Panman, Janne Papma, Michela Pievani, Yolande Pijnenburg, Enrico Premi, Sara Prioni, Catharina Prix, Rosa Rademakers, Veronica Redaelli, Ekaterina Rogaeva, Pedro Rosa-Neto, Giacomina Rossi, Martin Rosser, Beatriz Santiago, Elio Scarpini, Sonja Schönecker, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L. Thomas, Hakan Thonberg, Carolyn Timberlake, Pietro Tiraboschi, Philip Vandamme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Elisabeth Wlasich, Henrik Zetterberg, Miren Zulaica
Neurobiology of Aging  ·  01 May 2019

2018

Thomas E Cope, Timothy Rittman, Robin J Borchert, P Simon Jones, Deniz Vatansever, Kieren Allinson, Luca Passamonti, Patricia Vazquez Rodriguez, W Richard Bevan-Jones, John T O'Brien, James B Rowe
Brain  ·  01 Jun 2018

2016

Timothy Rittman, Ian T.S. Coyle-Gilchrist, James B Rowe
Neurodegenerative Disease Management  ·  01 Nov 2016
Petra E. Vértes, Timothy Rittman, Kirstie Jane Whitaker, Rafael Romero-Garcia, František Váša, Manfred Kitzbichler, Peter Fonagy, Raymond J Dolan, Peter B Jones, Ian M Goodyer, NSPN Consortium, Edward T Bullmore
Philosophical Transactions of the Royal Society B  ·  01 Jun 2016
Timothy Rittman, Mika Rubinov, Petra E. Vértes, Ameera X Patel, Cedric Ginestet, Boyd C P Ghosh, Roger A. Barker, Maria Grazia Spillantini, Edward T Bullmore, James B Rowe
Neurobiology of Aging  ·  01 Jun 2016

2013

Timothy Rittman, Boyd C P Ghosh, Peter McColgan, David P Breen, Jonathan R Evans, Caroline H Williams-Gray, Roger A Barker, James B Rowe
Journal of Neurology, Neurosurgery & Psychiatry  ·  08 Jan 2013

1970

Nicholas Yew Wei Heng, Timothy Rittman
Brain Communications  ·  01 Jan 1970

Funding

Our work is made possible by funding from several organizations.

Working with us

We are a collaborative group and would love to hear from similar research groups or companies working in the field of neurodegeneration.

We are open to PhD student applications through the Department of Clinical Neurosciences application process. We are growing and have occasional post-doctoral and other positions available. For more information, take a look at the teams page.